bromination of cholesterol mechanism

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Genetic demonstration of intestinal NPC1L1 as a major determinant of hepatic cholesterol and blood atherogenic lipoprotein levels. 290, 2346423477 (2015). Trends Biochem. 41, 457463 (2016). USA 108, 551556 (2011). This work identifies that IDOL is an LXR target gene and that the IDOL protein promotes ubiquitylation and degradation of LDLR in the extrahepatic tissues in mice. Biol. Abstraction of hydrogen by a bromine atom is endothermic in both cases. Nat. Res. Pharmacokinet.

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